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Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed pharmacological actions.
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Ralph DeFronzo proposes treating diabetes with combination drug therapy rather than single medications

These beneficial effects may be related to the alleviation of GPX4 promoter hypermethylation
