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Similarly, serotonin levels did not change after insulin injection in mice (2 U/kg, i.p.) (Supplemental Figure 16, D and E) as compared with equal-volume saline at either 15 minutes (insulin: 430 166 ng/mL

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Further, GLP-1RAs play a neuroprotective effect by stimulating the differentiation of nerve cells and inhibiting neuroinflammation (8), while they were also reported to inhibit liver inflammation (9)

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There is no direct head-to-head trial, but the mechanistic difference, particularly the addition of glucagon receptor activity increasing energy expenditure, distinguishes the two compounds

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