how do glp 1 drugs work Anti-obesity are closing the gap between dieting and bariatric surgery | Diet and Nutrition | Prevention How GLP-1 Medications Work: What

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Mechanism In response to a previous FDA inquiry, two short-term mechanical studies were conducted using exenatide and liraglutide in a diabetic rat model, wherein one rat administered with exenatide died of pancreatic necrosis, while the others exhibited acinar-to-ductal metaplasia and ductal hyperplasia, indicative of potential premalignant alterations [62,63]

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Intake of water-soluble dietary fiber, including pectins, gums, fructans and some resistant starches, has been shown to have many similar effects to the goals of GLP-1 therapy , such as: regulating both short and long-term glycemic control improving insulin sensitivity lowering blood cholesterol reducing the risk of cardiovascular disease 31,32 Both soluble and insoluble fibers also modulate microbiome composition and function, improving digestive health and supporting weight management

GIP may also influence fat metabolism and bone health, though these effects are still being investigated in humans