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Description
STEP-5 is the longest of the STEP trials, which spanned two years at semaglutide 2.4mg and reported gradual weight loss over the initial 60 weeks
The underlying mechanism and dosing may differ, requiring individualized medical assessment by a qualified provider
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Regarding kidney function, the DECREASE trial which enrolled 66 participants with obesity and type 2 diabetes showed a mean percentage change in 24-h urine albumin to creatinine ratio (UACR) of 40% with combination treatment including dapagliflozin and exenatide as opposed to 18% with dapagliflozin, 16% with exenatide and 11% with placebo [8], although between group differences did not reach statistical significance
The GLP-1RAs treatment reduces body weight and diminishes the risk of cardiovascular disease (CVD) [71,72]
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