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A series of (4-substituted prolyl) prolinenitriles as DPP-4 inhibitors were evaluated in a study by Kondo and coworkers (127)
Structural pharmacology advances are enabling the design of biased agonists and allosteric modulators, which may selectively engage beneficial signaling pathways while reducing side effects [133,134]
N Engl J Med 2021;385:15313
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Dutzmann J, Kefalianakis Z, Kahles F, Daniel JM, Gufler H, Wohlgemuth WA, et al
Alvarez-Villalobos NA, Trevino-Alvarez AM, Gonzalez-Gonzalez JG
