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doi: 10.1016/j.pharmthera.2022.108270

The profound anatomical and pathophysiological disparities between these models and human disease create a significant translational gap. Acknowledging these limitations is key to interpreting preclinical data cautiously and designing more relevant experimental paradigms

And so if I'm treating someone 65 years old, 70 years old for obesity and obesity-related complications, I am concerned about how much weight they're going to lose, because part of it will be muscle and they're not going to be able to build it back likely

The most effective strategies are: eating at scheduled times regardless of hunger, prioritizing protein at every meal, staying consistently hydrated, maintaining electrolyte balance, building in light-to-moderate resistance training, and protecting sleep quality