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However, whether these biochemical changes translate into meaningful clinical benefits remains uncertain
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No Published source: Diabetes Care , January 2016;39 (suppl 1):S1S112 Available at:

We speculate that increased intracellular cAMP levels after binding of GLP-1 on GLP-1R on the surface of CSMCs results in downregulation of NF-B phosphorylation and nuclear translocation which could ultimately result in a reduction in the expression of cytokines and chemokines (Figure 8)
