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While the trials were negative clinically, presenters and discussants noted biomarker changes consistent with reduced neuroinflammation (e.g., decreases in highsensitivity CRP) and other Alzheimersrelated signalsmodest but statistically significant effects that did not yield measurable cognitive benefit

doi: 10.1111/dom.13764
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As millions of patients are pushed to get on these drugs to aid in weight loss, there is cause for some worry, according to the report

Comparing Semaglutide, Tirzepatide, and Retatrutide Why Semaglutide Still Works for Some Patients Even though tirzepatide and retatrutide show greater average weight loss , not everyone needs (or tolerates) the most aggressive option

doi: 10.1016/j.ejphar.2025.178088, 35
