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Your assessment typically includes: A review of your medical history, including any existing conditions, medications you are taking, or allergies

By reducing hunger (and ameliorating the constant sense of deprivation often experienced with decreased portion sizes), prolonging the feeling of fullness after eating and, preventing over-eating, and reducing high-fat/ sugar cravings due to their natural effect on the brains reward system, they support gradual and sustainable weight loss when combined with dietary and lifestyle changes

A #randomized controlled trial (n=800) demonstrated that the #GLP-1 receptor agonist, #semaglutide, administered for 72 weeks, led to: #Improved fibrosis in 37% of patients vs 22% with placebo #Resolution of steatohepatitis #Significant metabolic benefits including weight reduction and improved glycemic control #Based on these findings, in August 2025 the FDA approved #semaglutide for the treatment of MASH, marking a major milestone in hepatology and metabolic medicine

Among those using medication for weight loss, 15% (about one in seven) were using medication not licensed for this purpose (such as Rybelsus licensed in the UK for type 2 diabetes only)

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Most comparisons showed low to moderate evidence quality, and the studys limitations, inconsistencies, indirectness, and imprecision were the key reasons for the decline in confidence