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Amycretin is a next-generation unimolecular dual GLP-1/amylin receptor agonist that showed up to 24.3% weight loss in early trials, substantially exceeding semaglutide and potentially exceeding even CagriSema

doi: 10.1172/JCI200420518

As well, excessive dietary protein that is above the needs for repair or growth can be converted to fat by the liver and increase visceral adiposity (Mozafariun et al 2025)

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