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Asterisks indicate a statistically significant difference by 1-way ANOVA with Tukey HSD post hoc test

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Long-term opioid use, including methadone maintenance therapy (MMT), can have significant side effects, including dependence, cognitive impairment, and others

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Severe or recurrent genital mycotic infections and urinary tract infections warrant treatment suspension if they become problematic ( Canagliflozin specifically should be discontinued in patients with a heightened risk of amputations, including those with a history of amputations, severe peripheral neuropathy, severe peripheral arterial disease, or active lower-limb ulcers or infections, as well as in individuals with an increased fracture risk, particularly those with previous osteoporotic fractures ( 3.3 Mechanism of action of GLP1 receptor agonists GLP-1 is a hormone belonging to the incretins that is produced in the gastrointestinal tract, by L cells, in response to the intake of nutrients, especially fat and glucose (43)

To find out which medicine, or combination of medications, is most appropriate for their unique medical needs and lifestyle, patients should speak with their healthcare providers