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Lancet (2021) 397:97184

Although the American Diabetes Association recommends metformin treatment as a first-line therapy, metformin treatment alone is insufficient to achieve target blood glucose level in most patients1)

As discussed above, lipopolysaccharides (LPS) could prompt inflammation and amyloidogenesis in the brain, by inducing the disorder of TNF-a, IL-1, and cyclooxygenase-2 (COX-2) (87)