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Well, research suggests that adipose tissue (body fat) produces hormones, including estrogen, that may directly influence the uterine lining and contribute to heavier menstrual bleeding in people with higher BMIs

[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Umapathysivam M.M., Lee M.Y., Jones K.L., Annink C.E., Cousins C.E., Trahair L.G., Rayner C.K., Chapman M.J., Nauck M.A., Horowitz M., et al

25 Safety issues and precautions for the use of semaglutide in special populations The more frequent adverse events associated with the use of GLP-1 RA were gastrointestinal reactions, such as nausea, vomiting, and diarrhea

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Lower risk for cardiovascular events