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Description
JAMA (2017) 318(15):146070
Short-acting GLP-1RAs like exenatide and lixisenatide are associated with transient (112 h) increases, causing a maximum heart rate increase of 810 beats per minute (bpm) 24 h after injection, which returned to baseline after approximately 1012 h, with a mean 24 h heart rate increase of approximately 12 bpm for both GLP-1RAs in healthy adults ( Linnebjerg et al

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But tirzepatide concentrations are different from semaglutide concentrations, and the therapeutic dose ranges are different
In Phase 2 and Phase 3 trials , retatrutide has demonstrated HbA1c reductions and weight loss, but these dosages are intended for clinical research only