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You need to take it on an empty stomach with no more than 4 ounces (oz) of plain water and wait at least 30 minutes before eating breakfast or drinking a cup of coffee

As liquids flow more rapidly than viscous and solid materials, liquids with small suspended particles are swept across the pylorus into the duodenum, whereas the viscous and solid mass of the chyme is retained in the stomach

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For more info on constipation causes and treatment check out Cleaveland Clinic Does constipation go away on GLP-1

Emily's Experience with Tirzepatide First Results: Weight Loss and Appetite Control Emily's journey with Tirzepatide has been straightforward and impactful