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The arrival of two approved oral GLP-1 weight loss therapies in the space of four months has fundamentally redrawn the obesity treatment landscape in 2026

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Hazard ratios (HR) along with 95% confidence intervals (CI) were used to compare the time to the event rates of intestinal obstruction

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Daniel Drucker, a professor at the University of Toronto Faculty of Medicine in Canada and a former adviser to Eli Lilly, said, "It shows the most powerful weight-loss effect among GLP-1 drugs developed so far" and evaluated it as "an effect on par with bariatric surgery (metabolic surgery for obesity)." He added, "If approved, most patients who need substantial weight reduction will choose retatrutide."