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indeed, although it reaches the brain via endocrine mechanisms, it also acts locally by activating GLP-1R present on the dendritic terminals of the vagus nerve that innervate the gut, thus mediating the inhibition of food intake as well as relaying the satiety signal to the brain

Some researchers have reported unexpected pregnancies while on tirzepatide, likely because improved metabolic health can restore ovulation in women with weight-related anovulation

Lead author Dr Simon Cork, Physiology lead at Anglia Ruskin Universitys School of Medicine, said: This new review provides one of the most comprehensive analyses so far of how GLP1 drugs interact with the underlying mechanisms of Alzheimers

However, studies have shown that retinal layer thickness is significantly lower in pwIIH compared to healthy controls, meaning that axonal loss is more widespread than previously suspected, and also occurs in apparently effectively treated pwIIH and/or patients not reporting any visual disturbances at all [35]

What Are GLP-1 Drugs and Why Do They Matter