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10.1016/j.neuron.2009.04.017 [DOI] [PMC free article] [PubMed] [Google Scholar] de Miranda A

Drucker Peripherally administered GLP-1R agonists reduce food intake and body weight through signaling mechanisms requiring functional GLP-1Rs in the ARC of the hypothalamus

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Tirzepatide targets both GLP-1R and the glucose-dependent insulinotropic peptide receptor (GIPR), while the older two medications focus on GLP-1R alone
Recent headlines about Medicare GLP-1 price cuts for medications like Ozempic and Wegovy have generated significant patient interest and questions in weight loss practices across the country
