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Discussion The intestinal epithelial barrier is usually the first site to be involved in the inflammatory conditions affecting the gut, 24 where microorganisms or allergens are first encountered, leading to activation of the local immune cells and recruitment of new immune cells which alter the local environment resulting in the major hallmarks of inflammation

10.1152/ajpendo.1996.271.3.E458 43

That is the elegance of the semaglutide approach