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Phytonutrient genistein is a survival factor for pancreatic beta-cells via GPR30-mediated mechanism

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Sensitivity analysis reveals the degree of robustness of the results as follows ( Supplementary Figures S3, S4 ): i) Primary outcome & secondary outcomes (nonfatal stroke, all-cause death, HF hospitalization): Excluding any single study did not alter the direction and magnitude of effects, confirming robustness

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The pharmacokinetics were also assessed in subjects with overweight (BMI 27 to 29.9 kg/m 2 ) or obesity (BMI greater than or equal to 30 kg/m 2 ) and mild to moderate renal impairment, based on data from clinical trials

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