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Cellular Neuroadaptations to Chronic Opioids: Tolerance, Withdrawal and Addiction

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Additionally, spreading meals evenly throughout the day and avoiding late-night eating supports natural GLP1 rhythms

The theoretical concern is additive effects on insulin sensitivitybeneficial in some contexts, but potentially requiring dose adjustment or monitoring in others

Zheng Z-H, Tu J-L, Li X-H, Hua Q, Liu W-Z, Liu Y, et al

We've been using them safely in medicine for decades nicotine replacement, hormone replacement therapy (HRT), some pain medications, motion sickness drugs, certain heart treatments