glp 1 agonist eye side effects GLP-1RA Essentials in Gastroenterology: Effect Management, Precautions for Endoscopy and Applications for Gastrointestinal Disease Treatment Doctor Explains GLP 1 Blindness

[DOI] [PubMed] [Google Scholar] 404.Huang Y., Wilkinson G.F., Willars G.B

While peripherally administered GLP-1 seemingly crosses the blood brain barrier (BBB) via simple diffusion, the half-life of GLP-1 is less than 2 min, leading to disagreement regarding whether peripherally derived GLP-1 is what activates CNS GLP-1R under physiological conditions

doi: 10.1007/s12020-020-02223-6 12 BrownJCDryburghJRRossSADuprJ

The answer lies in balance

In the phase 2b trial, however, the reductions in glycated hemoglobin and body weight in participants treated with NNC0090-2746 were similar to those in the group treated with liraglutide (76), and no phase 3 trial of NNC0090-2746 has been reported yet

Diabetes Obes Metab 2011;13:348356