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"GLP-1 Receptor Agonist Use Associated with Lower Ferritin Levels." [7] Michigan Medicine

Any dose reduction strategy represents off-label clinical judgment and should be discussed with your prescribing physician, who may suggest gradually reducing the dose by one step every 46 weeks based on individual circumstances

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10 GLP-1, a peptide hormone, is generated by enteroendocrine cells at low baseline levels and by neurons in the caudal medulla

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GLP-1RA of Exendin-4 mainly inhibited bone resorption by regulating OPG/RANKL ratio, and increases the expression of osteogenic related genes OC, COL1, Runx2, and ALP to promote bone formation (Ma et al., 2013)