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The cost advantages of oral production are often offset by higher dosing requirements and lower bioavailability

Qi T, Ly K, Poyner DR, et al

SURPASS-2 Investigators

Dermatologic Implications of Glucagon-Like Peptide-1 Receptor Agonist Medications

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On the other hand, their pleiotropic actions, frequent involvement of the central nervous system, and context-dependent effects have historically rendered them unattractive as therapeutic targets