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Endocrine changes in Prader-Willi syndrome

Allodynia is a symptom of neuropathic pain characterized by pain in response to stimuli that would not normally provoke discomfort

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doi: 10.1111/jdi.12445 12 TakedaYFujitaYYanagimachiTMaruyamaNBesshoRSakagamiHet al

Beyond weight outcomes, the Phase 2 obesity trial also reported improvements in several cardiometabolic markers, including: Reductions in waist circumference Improvements in fasting glucose and insulin sensitivity Favourable changes in blood pressure and lipid profiles Phase 3 trials understood to form part of the TRIUMPH programme are now underway, evaluating retatrutide in broader populations including people with type 2 diabetes and cardiovascular disease