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Description
Semaglutide, tirzepatide, and retatrutide (Biosynth, Compton, UK, lot #s 0000042482, 0000054911, and 0000205204 respectively) were dissolved in 0.3% phosphate-buffered saline (PBS), which was adjusted to a pH of 8.0 using NaOH and injected subcutaneously (s.c.) at 1 ml/kg

All studies investigated the efficacy and tolerability of retatrutide, survodutide, cotadutide, or mazdutide in patients with diabetes, overweight and/or obesity
Messer and Dr

Nat Commun 13:4477

doi: 10.1053/j.gastro.2021.01.230

At negative 20 degrees Celsius or colder, lyophilized retatrutide remains stable for up to 48 months
