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It has recently been reported that human GLP-1 analogues were more effective in reducing the occurrence of major adverse cardiovascular events, myocardial infarctions, and hospitalizations due to cardiovascular causes when compared to exendin-based GLP-1RAs [71]

Naunyn Schmiedebergs Arch Pharmacol

Pfizer terminated lotiglipron in October 2023 due to dose-dependent liver enzyme elevations, and subsequently discontinued danuglipron in April 2025 after a single case of potential drug-induced liver injury was identified in a dose-optimization study

Ozempic: Originally for diabetes but widely used off-label for obesity

Importantly, as shown in a subset of patients, no significant cross-reaction was observed between anti-exenatide antibodies and human GLP-1 or glucagon

Identification of a regulatory pathway of l-phenylalanine-induced GLP-1 secretion in the enteroendocrine L cells