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Understanding this difference helps patients choose the right weight loss therapy for their metabolic needs

Glucagon-like peptide 1 (GLP-1) is a cleavage product of the pre-proglucagon gene which is expressed in the -cells of the pancreas, the L-cells of the intestine, and neurons located in the caudal brainstem and hypothalamus

The results prompt safety concerns for GLP-1RAs, especially with high dose administration, regarding gastrointestinal adverse events

Future research should prioritize human trials, bioavailability optimization, and synergistic formulations to harness the full therapeutic potential of plant-derived GLP-1 agonists in metabolic disorders.

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