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Studies investigating different coformulations of semaglutide and SNAC in healthy individuals showed that exposure of semaglutide 5 or 10 mg was higher with 300 mg SNAC compared with 150 or 600 mg, demonstrating that 300 mg SNAC is the optimal amount of SNAC to enhance the absorption of semaglutide (15,37)

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For the efficacy outcomes (HbA 1c and body weight), treatment differences were estimated by a mixed model for repeated measurements (MMRM) using data collected prior to premature trial product discontinuation or initiation of rescue medication from all randomised patients

Gastrointestinal adverse effects, infections, retinopathy, malignant neoplasms and 3 cardiovascular adverse events were reported