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These medications, such as semaglutide and tirzepatide, have been game-changers for many seeking effective weight management solutions

There is still a negative deflection for 9/12mg arms suggesting we have not reached max reduction in A1c and keep in mind this is retatrutide alone, with no other medications allowed

2018;7:e009379

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A notable safety signal is dysaesthesia, which refers to tingling, numbness, or altered skin sensations, reported in about 1 in 5 participants at the 12 mg dose

Whether longer-acting versions, perhaps weekly insulinGLP-1 combinations, are feasible and efficacious requires additional investigation