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The psychological benefits, including enhanced self-esteem and reduced anxiety, are just as important as the physical ones

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But we know that for patients with HFpEF and obesity, a maximum of 10% body weight reduction can be achieved through both diet and exercise (in the structured and supervised clinical trial setting) but quality of life remains markedly impaired

However, the absence of documented cases does not definitively exclude the possibility of an association, particularly given the relatively recent widespread use of semaglutide