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Anti-obesity pharmacotherapies, especially glucagon-like peptide 1 receptor agonists and tirzepatide, preferentially reduce fat mass while partially sparing skeletal muscle, though significant lean mass loss has been described in individuals with pronounced weight reduction

According to the company's published study, over 95% of patients reported side effects as minimal or moderate but manageable

It often requires active management through increased fiber intake, adequate hydration, and sometimes stool softeners

Some people prefer evening injections so they sleep through the initial nausea window

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Devesa J, Almengl C, Devesa P