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By improving insulin sensitivity and reducing overall caloric intake through appetite suppression, semaglutide addresses a core metabolic dysfunction in PCOS

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A separate systematic review of 26 RCTs involving 15,491 participants found placebo-adjusted weight loss of approximately 22% for retatrutide 12mg, 18% for tirzepatide 15mg, and 14% for semaglutide 2.4mg, an effect-size hierarchy consistent across analyses

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