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Vasodilation is hampered, and thrombosis is encouraged by decreased nitric oxide production

Patients receiving sitagliptin with metformin immediate-release and insulin had significant improvements in A1C, FPG and 2-hour PPG compared to patients receiving placebo with metformin immediate-release and insulin (Table 13)

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For ischemic stroke and retinal damage, two major complications of diabetes mellitus, it was shown that DPP-4 inhibition prevented inflammation and mediated neuroprotective effects (68, 89)