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Enhanced lipolysis in the adipose tissues of insulin resistant patients enhances the influx of FFAs to the liver which in turn worsens hepatic steatosis and insulin resistance

doi: 10.1016/j.ejphar.2013.06.023 113 HuangZWangHLuMSunCWuXTanYet al

[DOI] [PubMed] [Google Scholar] 805.Hansotia T., Maida A., Flock G., Yamada Y., Tsukiyama K., Seino Y., et al

As a signaling molecule, GLP-1 increases the bodys sensitivity to insulin, the hormone responsible for controlling blood sugar levels

Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

In addition to lifestyle changes, GLP-1 RAs have been shown to lower body weight in a range of 27 kg through early satiety and reduction in appetite, thus lowering caloric intake [31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50]