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The combination of GIPR dominance and GLP-1R bias toward cAMP signals results in enhanced insulin secretion, improved metabolic parameters, and a more tolerable GI side effect profile 2,3,4

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[DOI] [PMC free article] [PubMed] [Google Scholar] 62.Liraglutide and cardiovascular outcomes in type 2 diabetes

However, caution should be given to this review because most studies were from high-income countries and insulin degludec/liraglutide (IDegLira) was included in the GLP-1RA group

Liraglutide and Cardiovascular outcomes in type 2 diabetes