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Possible side effects of naltrexone/bupropion HCL (Contrave) Contrave pairs two medications, both of which act on the opioid pathway in the brain

These models may not fully recapitulate the chronic, multifactorial nature of human ocular diseases like DR, which involves decades of metabolic dysregulation and low-grade inflammation [130,131,132,133]

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Potential adverse effects of these drugs include hypoglycemia (when taken with insulin), GI distress, and injection site reactions