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These medications work by mimicking the natural incretin hormone GLP-1, which stimulates insulin secretion in response to food intake, suppresses glucagon release, slows gastric emptying, and reduces appetite

Liraglutide (Victoza / Saxenda) Liraglutide was one of the earlier GLP-1 receptor agonists to reach the market, approved first for diabetes and later for weight loss under the brand name Saxenda

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This matches a broader finding that CVS plans technically cover Wegovy in just 18% of their employer-sponsored formularies (2026 data) ( [4] )

Nat Med (2021) 27:12729

Introduction What are Tirzepatide and Semaglutide