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The rising obesity rates are closely linked to an increase in obesity-related comorbidities, including type 2 diabetes, hypertension, cardiovascular diseases, and certain cancers

Looking ahead, Novo Nordisk announced in February 2026 that the list price of Rybelsus will drop to $675 per month starting January 1, 2027a reduction of approximately 35%

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Liraglutide has been shown to increase renal endothelial nitric oxide synthase (eNOS) levels by downregulating NF-B in STZ-induced diabetic rats (Zhou et al., 2014)

Meanwhile, in December 2025, the FDA approved oral Wegovy a once-daily semaglutide 25 mg tablet as the first oral GLP-1 for weight management ( [19] )