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The RASS trial was a controlled trial involving 223 normotensive patients with type 1 diabetes and normoalbuminuria and who were randomly assigned to receive losartan, enalapril, or placebo (50)

Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation

Setmelanotide (Imcivree) licensed for the treatment of obesity caused by specific rare genetic conditions (including pro-opiomelanocortin [POMC] deficiency and leptin receptor deficiency)

Sulfonylurea, insulin were stopped first DPP-4 inhibitors early because of cost/benefit GLP-1 and metformin were deprescribed last

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