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doi: 10.1038/sj.emboj.7600244

Factors favoring GLP-1 therapy Type 2 diabetes with preserved beta cell function

73 Besides, the PKA pathway may also be involved in GLP-1, attenuating the ER stress signaling pathway and protecting cells from apoptosis

A 2025 narrative review of clinical trials confirmed that across completed randomised and indirect comparisons, tirzepatide consistently outperforms semaglutide in body weight and HbA1c reduction [2]

Each comes with its own dosing and indications

Standard semaglutide or tirzepatide pens are available with a fixed strength
