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Other options include SGLT2 inhibitors such as dapagliflozin or empagliflozin, DPP-4 inhibitors like sitagliptin, or traditional agents such as metformin (if not already prescribed), sulfonylureas, or insulin therapy

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This physiological change can lead to feelings of fullness, bloating, and altered bowel habits

Poor adherence will adversely affect the plan sponsors performance for this measure despite the medication being used inappropriately off-label

However, as with any treatment, it is important to consider potential semaglutide side effects, particularly gastrointestinal symptoms that may occur during dose escalation

Cost Accessibility and No-Insurance Options for Year-Round Semaglutide One barrier to extended semaglutide use is cost, but PlexusDx removes insurance requirements and membership fees by offering direct-to-patient compounded semaglutide starting at $149 per month across all tiers