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Wegovy (semaglutide 2.4 mg) ~15% mean weight loss at ~68 weeks Strongest CV outcomes and long-term safety base Still a blockbuster but clearly behind on magnitude

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Clinical Nutrition Interventions the goal is risk reduction, symptom control, and recurrence prevention Balanced fat intake (not fat elimination) to promote gallbladder emptying Preference for unsaturated fats (MUFA & omega-3s) Adequate dietary fiber improves bile acid turnover Avoidance of extreme calorie restriction Glycemic control to reduce cholesterol supersaturation Post-cholecystectomy nutrition support to manage bile flow changes Gallstones are a metabolic consequence, not just a gallbladder issue

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