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Nevertheless, it seems quite reasonable to think that the BBB is no longer an impenetrable barrier

The molecule was developed by Frank Ng's group at Monash University and Metabolic Pharmaceuticals in Australia during the 1990s and 2000s as a potential anti-obesity drug intended to isolate the lipolytic region of hGH without activating the growth hormone receptor or raising IGF-1.nnIn published preclinical work, the fragment has been shown to stimulate lipolysis, suppress lipogenesis, and modulate the beta-3 adrenergic receptor pathway in adipose tissue rather than acting through the classical hGH receptor

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doi: 10.1038/s41598-020-67443-2 [DOI] [PMC free article] [PubMed] [Google Scholar] 240