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At 72 weeks, the mean percentage change in weight was -20.9% with 15 mg of tirzepatide, as compared with -3.1% with placebo. SURMOUNT-1, per Jastreboff AM et al

Before this approval, only branded GLP-1 drugs, including Saxenda and Wegovy (semaglutide), were available for weight loss, limiting patient access

Start to medication, you are often looking at days, not weeks

Four of the six genes investigated by quantitative RT-PCR were significantly up-regulated by Exendin-4 pre-conditioning, including Lactate dehydrogenase A ( Ldha ), Aldolase A ( Aldoa ), Phosphofructokinase ( Pfkp ) and Glucose-6-phosphate isomerase ( Gpi ) (Fig

A randomised trial found semaglutide reduced drinking in people with alcohol use disorder

New evidence from a study lead by Prof Onur Baser supports the role of GLP-1 therapies in managing obesity-related obstructive sleep apnea (OSA)