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Obesity, together with ageing, remains the most important risk factor as regards the occurrence and progression of osteoarthritis (OA) not only by overloading the joints with the consequent destruction of articular cartilage, but also by alterations in innate and adaptive immune responses that could lead to inflammatory cell recruitment into the synovial joints [184]
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Incidences of adverse events were derived from the SUSTAIN 7 [15], and the treatment costs for adverse reactions were obtained from the previous literature [20, 32] and expressed in the 2023 Chinese yuan

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