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The most common are gastrointestinal: nausea, vomiting, diarrhea, constipation, bloating, and reduced appetite
The physiological effects of GIP, GLP-1, and GLP-1RAs on bone metabolism have not yet been determined, and studies are needed to examine the effects of gut hormone on human osteoblast differentiation and osteoclast activity, including their potential interactions with Wnt and NF-kB signaling
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8 Direct action on the skin is a possible mechanism, as GLP-1Rs have been shown to be expressed in the skin of newborn mice and cultured skin cells
It is taken orally in the form of a capsule
