glp-1 news today november 2025 Receptor Agonists and vision risk Could GLP-1 Receptor Agonists Help

Medication Options and Costs Medication Monthly cost Compounded semaglutide injections $189 first month

STEP-HFpEF Trial (NEJM, 2023): 13.3% weight loss plus major improvements in HFpEF symptoms and function

Market Expansion & Competition Rival GLP-1 pills are in late-stage development, including Eli Lillys orforglipron , which could be approved in 2026

NICE guidelines (NG28) recommend reviewing GLP-1 treatment at around 6 months and continuing only if there has been a meaningful reduction in HbA1c (typically at least 11 mmol/mol [1%]) and weight loss of at least 3% of initial body weight

This showed us that GLP-1 and GIP are not as effective in shutting down glucagon and stimulating insulin secretion in patients with kidney disease compared to controls, suggesting increased resistance to their action in CKD, Ahmadi added

Patients must wait at least 30 minutes before eating, drinking, or taking other medications