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2.8%, hazard ratio ( HR ) = 0.51, 95% CI 0.310.84] and cardiovascular mortality (0.9% vs
GIP is the main incretin hormone in healthy people, causative of most the incretin effects, but the insulin response after GIP secretion in type 2 diabetes mellitus (T2DM) is strongly reduced

2025;20:e70024

A Russian cohort study indicated a nominal association between T2DM PRS and anhedonia, a core symptom of MDD, though the findings did not withstand correction for multiple comparisons [63]

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120 Variations in genes related to bile acid metabolism, cholesterol transport, and gallbladder motility can significantly influence susceptibility