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James Januzzi, MD Although our primary endpoint fell short of statistical significance, there are encouraging signals in these results that increase enthusiasm to further evaluate effects of AT-001 on diabetic cardiomyopathy, saidJames Januzzi, MD, Hutter Family Professor of Medicine atHarvard Medical School, a cardiologist atMassachusetts General Hospital, director of Heart Failure Trials at theBaim Institute for Clinical Researchand the studys lead author

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Across conditions, 24-h concentration profiles of GLP-1 were characterized by the expected postprandial increases (P<0.001)

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Initial research has indicated that low-dose semaglutide injections can reduce alcohol craving and some drinking outcomes, prompting calls for a larger clinical trial to evaluate GLP-1RAs for alcohol use disorder.